Analysis of severity course and mortality in relation to sex and age among patients with novel coronavirus infection during the COVID-19 pandemic: experience from a large medical organization in the Ryazan Region
Objective. Analysis of the severity and mortality rates by gender and age in patients with novel coronavirus infection during the COVID-19 pandemic, based on the experience of a large medical organization in the Ryazan Region.Kraushkina A.A., Martynov V.A., Filippov E.V., Lobas V.D., Kirina A.A.
Materials and methods. A retrospective study involving 19,223 patients with COVID-19 registered in the patient registry of the N.A. Semashko Regional Clinical Hospital of the Ryazan Region from January 31, 2020, to November 19, 2024 was conducted. Age and gender characteristics, disease severity, and mortality in the cohort were analyzed.
Results. Women accounted for 62.4% of the cases, while men accounted for 37.6%, with a predominance of women in all age groups. The highest proportion (29.1%) of cases were in the 61–74 age group. The likelihood of hospitalization increased in patients over 45 years of age. Women predominated among inpatients (56.4%), but the hospitalization rate for men was higher. The overall mortality rate in the cohort was 3.9%. Across all age groups (except 18–24 years), mortality was higher among men and increased with age. The majority of deaths occurred among inpatients (13.96%). The risk of developing severe forms of the disease in the entire cohort increased with age and peaked in older age groups. Men in the entire cohort were significantly more likely to have moderate, severe, and extremely severe disease.
Conclusion. The obtained data are consistent with the results of international studies emphasizing the influence of patient age on the incidence, severity, and mortality of novel coronavirus infection; however, they have specific characteristics within the healthcare organization.
Keywords
novel coronavirus infection
COVID-19
inpatient treatment
outpatient treatment
mortality
incidence
patient characteristics
pandemic
Ryazan Region
References
- Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497–506. DOI: 10.1016/S0140-6736(20)30183-5
- Pirhadi R., Talaulikar V.S., Onwude J., Manyonda I. Could estrogen protect women from COVID-19? J. Clin. Med. Res. 2020; 12(10): 634–639. DOI: 10.14740/jocmr4303
- Gemmati D., Bramanti B., Serino M.L., Secchiero P., Zauli G., Tisato V. COVID-19 and individual genetic susceptibility/receptivity: role of ACE1/ACE2 genes, immunity, inflammation and coagulation. Might the double X-chromosome in females be protective against SARS-CoV-2 compared to the single X-chromosome in males? Int. J. Mol. Sci. 2020; 21(10): 3474. DOI: 10.3390/ijms21103474
- Chen R., Liang W., Jiang M., Guan W., Zhan C., Wang T. et al. Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China. Chest 2020; 158(1): 97–105. DOI: 10.1016/j.chest.2020.04.010
- Акимкин В.Г., Кузин С.Н., Семененко Т.А., Плоскирева А.А., Бартеньева И.В., Гореликова Е.А. и др. Гендерно-возрастное распределение пациентов с COVID-19 на разных этапах развития эпидемии в Москве. Проблемы особо опасных инфекций 2020; (3): 27–35. [Akimkin V.G., Kuzin S.N., Semenenko T.A., Ploskireva A.A., Barteneva I.V., Gorelikova E.A. et al. Gender-age distribution of patients with COVID-19 at different stages of epidemic in Moscow. Problems of Particularly Dangerous Infections 2020; (3): 27–35. (In Russ.)]. DOI: 10.21055/0370-1069-2020-3-27-35
- Кицул И.С., Вечорко В.И., Кац Д.В., Сычев Д.А. Анализ состава госпитализированных пациентов с новой коронавирусной инфекцией COVID-19. Здравоохранение Российской Федерации 2021; 65(3): 183–90. [Kitsul I.S., Vechorko V.I., Kats D.V., Sychev D.A. Analysis of the composition of hospitalized patients with the new coronavirus infection COVID-19. Health Сare of the Russian Federation 2021; 65(3): 183–90. (In Russ.)]. DOI: 10.47470/0044-197X-2021-65-3-183-190
- Левченко К.В., Гопоняко, С.В., Буйневич И.В., Кравченко А.М., Семенова Л.Н. Половозрастная и клиническая характеристика госпитализированных пациентов с пневмонией, вызванной SARS-CoV-2. В кн.: БГМУ в авангарде медицинской науки и практики: сб. науч. трудов. Минск: БГМУ, 2021; Вып. 11: 194–198. [Levchenko K.V., Goponyako, S.V., Buinevich, I.V., Kravchenko A.M., Semenova L.N. Gender-age and clinical characteristics of hospitalized patients with pneumonia caused by SARS-CoV-2. In: BSMU in the forefront of medical science and practice: collection of scientific works. Minsk: BGMU; 2021. Issue 11: 194–198. (In Russ.)].
- Балахонов С.В., Дугаржапова З.Ф., Чеснокова М.В., Семенова В.М., Лященко С.М., Борзенко М.А. и др. Эпидемиологические особенности пандемии COVID- 19 в 10 субъектах Сибирского и Дальневосточного федеральных округов (2020–2023 гг.): информ. бюлл. Иркутск, 2024. 44 с. [Balakhonov S.V., Dugarzhapova Z.F., Chesnokova M.V., Semenova V.M., Lyashchenko S.M., Borzenko M.A. et al. Epidemiological features of the COVID-19 pandemic in 10 subjects of the Siberian and Far Eastern Federal Districts (2020–2023): information bulletin. Irkutsk, 2024. 44 p. (In Russ.)].
- Фомин В.В., Роюк В.В., Решетников В.А., Волкова О.С., Коршевер Н.Г., Козлов В.В. Анализ внутрибольничной летальности у пациентов с новой коронавирусной инфекцией (COVID-19) Клинического центра Сеченовского университета. Российский медико-биологический вестник имени академика И.П. Павлова 2023; 31(3): 381–389. [Fomin V.V., Royuk V.V., Reshetnikov V.A., Volkova O.S., Korshever N.G., Kozlov V.V. Analysis of in-hospital mortality in patients with new coronavirus infection (COVID-19) at the Clinical Center of Sechenov University. I.P. Pavlov Russian Medical Biological Herald 2023; 31(3): 381–389. (In Russ.)]. DOI: 10.17816/PAVLOVJ569334
- Панасюк Я.В., Чурилова Н.С., Власенко Н.В., Дубоделов Д.В., Клушкина В.В., Кузин С.Н. Характеристика эпидемиологической ситуации COVID- 19 в Нижегородской области в период от 26 февраля 2020 г. до 22 июля 2020 г. Сб. материалов Всерос. науч.-практ. конф. с международным участием «Молекулярная диагностика и биобезопасность». М., 2020: 165–167. [Panasyuk Ya.V., Churilova N.S., Vlasenko N.V., Dubodelov D.V.. Klushkina V.V.. Kuzin S.N.Characteristics of the epidemiological situation of COVID-19 in the Nizhny Novgorod Region in the period from February 26, 2020, to July 22, 2020. Collection of materials from the All-Russian Scientific and Practical Conference with International Participation «Molecular Diagnostics and Biosafety» 2020: 165–167. (In Russ.)]. DOI: 10.36233/978-5-9900432-9-9-165
- Дубоделов Д.В. Эпидемиологическая характеристика случаев COVID-19 в Ставропольском крае в период с 19 марта 2020 г. по 12 августа 2020 г. (Электронный ресурс). [Dubodelov D.V. Epidemiological characteristics of covid-19 cases in the Stavropol territory during march 19, 2020 to august 12, 2020. (Electronic resource). (In Russ.)]. https://covid19-preprints.microbe.ru/article/134?ysclid=mm51mni84d167451754
- Удовиченко С.К. Эпидемические проявления COVID-19 в Волгоградской области (Электронный ресурс). URL: https://covid19-preprints.microbe.ru/article/44?ysclid=mm51qhopzq91957403 [Udovichenko S.K. Epidemic manifestations of COVID-19 in the Volgograd region. (Electronic resource). URL: https://covid19-preprints.microbe.ru/article/44?ysclid=mm51qhopzq91957403 (In Russ.)]. DOI: 10.21055/preprints-3111740
- Урясьев О.М., Соловьева А.В., Смазнова О.А., Глотов С.И., Шурпо Е.М. Анализ взаимосвязи клинико-лабораторных и рентгенологических характеристик пациентов с COVID-19 в зависимости от исхода. Наука молодых (Eruditio Juvenium) 2024; 12(4): 501–511. [Uryas’ev O.M., Solov’eva A.V., Smaznova O.A., Glotov S.I., Shurpo E.M. Analysis of the Interrelation between Clinical, Laboratory and Radiological Characteristics of Patients with COVID-19 Depending on the Outcome. Science of the Young (Eruditio Juvenium) 2024; 12(4): 501–511. (In Russ.)]. DOI: 10.23888/HMJ2024124501-511
- Кислицина О.А., Чубарова Т.В. Факторы, влияющие на обращаемость россиян за медицинской помощью: гендерный аспект. Женщина в российском обществе. 2023; (2): 94–108. [Kislitsina O.A., Chubarova T.V. Factors influencing the appeal of Russians for medical care: gender aspect. Zhenshchina v Rossiiskom Obshchestve 2023; (2): 94–108. (In Russ.)]. DOI: 10.21064/WinRS.2023.2.7
- Triebelhorn J., Rüthrich M.M., de Miranda S.M.N., Schneider J., Westhoff T., Scherer M. et al. The impact of age, sex, and comorbidities on COVID-19 mortality of hospitalized patients during the SARS-CoV-2 pandemic: data from the multicentric prospective cohort study of the Lean European Open Survey on SARS-CoV-2 (LEOSS). Infection 2025; 53(6): 2481–2489. DOI: 10.1007/s15010-025-02583-z
- Mahmud M.A., Ayub H.H., Coyle P., Dyer A.H., Newsom R.C., Kenny R.A., et al. SARS-CoV-2 infection and the effect of age, sex, comorbidities, and vaccination among older adults: a national cohort study. Influenza and Other Respiratory Viruses 2023; 17(11): e13224. DOI: 10.1111/irv.13224
- Кудрявцева Н.А., Чорбинская С.А., Девяткин А.В., Барышникова Г.А., Колпаков Е.А., Самушия М.А. и др. Особенности клинического течения COVID-19 у лиц старших возрастных групп. Кремлевская медицина. Клинический вестник 2023; (4): 28–36. [Kudryavtseva N.A., Chorbinskaya S.A., Devyatkin A.V., Baryshnikova G.A., Kolpakov E.A., Samushiya M.A. et al. Features of the clinical course of COVID-19 in older age groups. Kremlevskaya Meditsina. Klinicheskii Vestnik 2023; (4): 28–36. (In Russ.)].
About the Authors
Anastasia A. Krayushkina, Аpplicant, Department of Infectious Diseases and Phthisiology, Department of Polyclinic Therapy, Academician I.P. Pavlov Ryazan State Medical University, Ministry of Health of the Russia; Infectiologist, N.A. Semashko Regional Clinical Hospital, Ryazan, Russia; bon.anastasiy@yandex.ru; https://orcid.org/0000-0002-0710-6524Professor Vladimir A. Martynov, МD, Head. Department of Infectious Diseases and Phthisiology, dr.martinov@mail.ru; https://orcid.org/0000-0001-7168-6642
Professor Evgeny V. Filippov, МD, Head., Department of Outpatient Therapy, Preventive Medicine and General Medical Practice, Academician I.P. Pavlov Ryazan State Medical University, Ministry of Health of the Russia, Ryazan, Russia; dr.philippov@vk.com; https://orcid.org/0000-0002-7688-7176
Valeria D. Lobas, 5th-year Student, Faculty of Pediatrics, Academician I.P. Pavlov Ryazan State Medical University, Ministry of Health of the Russia, Ryazan, Russia; lobasv232@gmail.com; https://orcid.org/0009-0000-8275-9958
Alina A. Kirina 5th-year Student, Faculty of Pediatrics, Faculty of Pediatrics, Academician I.P. Pavlov Ryazan State Medical University, Ministry of Health of the Russia, Ryazan, Russia; kirina.alina2002@mail.ru; https://orcid.org/0009-0006-2209-0950
Similar Articles
