Adherence to follow-up care and treatment in HIV patients admitted to a multidisciplinary hospital
Objective. Assessment of the risk structure of non-adherence to follow-up care and treatment for HIV infection in patients admitted to a multidisciplinary hospital.Kravchenko A.V., Elistratova T.A., Belyaeva V.V., Sokolova E.V.
Materials and methods. The study was conducted using direct written interviews with pre-prepared questionnaires after obtaining informed consent from the respondent. Sixty-eight patients (45 men and 23 women) aged 24 to 73 years were interviewed. Forty-two patients responded to the question about their antiretroviral therapy (ART) status. Twenty-nine patients were receiving treatment continuously, two patients interrupted therapy, and 11 patients were not receiving ART. Undetectable HIV RNA levels were noted in 31 survey reports. Eight patients died. Only one of the eight who died was receiving ART.
Results. The most common signs of cognitive decline were difficulty concentrating, word finding, and memory loss for recent events. Moderate and severe depressive symptoms were detected in 17.6% of respondents, and a positive alcohol abuse screening result was found in 22.5%. High levels of stigma associated with HIV infection were reported by 35.3% of patients. More than a quarter of patients were not receiving ART, and 4.8% of patients interrupted therapy. Statistically significant correlations were found between missed ART doses and forgetfulness (p = 0.000), severity of depressive symptoms (p = 0.002), alcohol abuse (p = 0.004), as well as low self-rated memory (p = 0.001) and health (p = 0.005).
Conclusion. The most significant risks for poor treatment adherence in HIV-infected patients were hostility related to HIV infection, a positive screening result for alcohol abuse, and forgetfulness.
Keywords
HIV infection
antiretroviral therapy
ART adherence
References
1. Покровский В.В., Ладная Н.Н. Вирус иммунодефицита человека в Российской Федерации в 2023 г. Эпидемиол. инфекц. болезни. Актуал. вопр. 2024; 14(3): 21–29. (Pokrovsky V.V., Ladnaia N.N. Human immunodeficiency virus in the Russian Federation in 2023. Epidemiоlоgy and infectious diseases. Сurrent items 2024; 14(3): 21–29. (In Russ.)). DOI: 10.18565/epidem.2024.14.3.21-9
2. Соколова Е.В., Беляева В.В., Козырина Н.В., Галиуллин Н.И., Семикова С.Ю., Бешимов А.Т. и др. Самооценка состояния здоровья как фактор прогноза приверженности диспансерному наблюдению и лечению ВИЧ-инфекции: результаты корреляционного анализа. Эпидемиол. инфекц. болезни. Актуал. вопр. 2021; 1(4): 61–65. (Sokolova E.V., Belyaeva V.V., Kozyrina N.V., Galiullin N.I., Semikova S.Yu., Beshimov A.T., Lebedeva E.P. et al. Self-assessment of health status as a factor for the prediction of adherence to follow-up and treatment of HIV infection: results of a correlation analysis. Epidemiоlоgy and infectious diseases. Сurrent items 2021; 1(4): 61–65. (In Russ.)). DOI: 10.18565/epidem. 2021.11.4.61-5
3. Беляева В.В., Соколова Е.В., Козырина Н.В., Голиусова М.Д., Кулабухова Е.И. Результаты скрининга пространственно-конструктивных навыков пациентов, длительно принимающих антиретровирусную терапию. Сб. трудов XVII Ежегодного Всероссийского конгресса по инфекционным болезням имени академика В.И. Покровского. М.: ММА, 2025: 32–33. (Belyaeva V.V., Sokolova E.V., Kozyrina N.V., Goliusova M.D., Kulabukhova E.I. Results of screening of spatial and constructive skills of patients taking long-term antiretroviral therapy. Proceedings of the Academician V.I. Pokrovsky XVII Annual All-Russian Congress on Infectious Diseases. Moscow: Medical Marketing Agency, 2025: 32–33. (In Russ.)).
About the Authors
Professor Alexey V. Kravchenko, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; alexey-kravtchenko@yandex.ru; http://orcid.org/0000-0001-7857-3763Tatyana A. Elistratova, Infectiologist, Head, Infectious Diseases Department, Tula Regional Clinical Hospital, Tula, Russia; Tatyana.Elistratova1@tularegion.org https://orcid.org/ 0009-0005-0145-3305
Valentina V. Belyaeva, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; labora-et-ora@yandex.ru; http://orcid.org/0000-0002-4621-7892
Ekaterina V. Sokolova, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; ekaterinasokolova007@rambler.ru; http://orcid.org/0000-0002-2001-8772
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