Clinical observations of the course of a new coronavirus infection in patients with chronic pulmonary tuberculosis and respiratory failure
Objective. Analysis of the clinical course of a new coronavirus infection in patients with chronic pulmonary tuberculosis (TB) and respiratory failure.Dobin V.l., Nikolaev A.N., Martynov V.A.
Materials and methods. We analyzed 6 case histories of patients with TB who fell ill with COVID-19 and were treated in a temporary infectious diseases department deployed at an anti-tuberculosis dispensary in 2021. The clinical course of a new coronavirus infection in 3 patients with chronic pulmonary T and respiratory failure in comparison with 3 patients without symptoms respiratory failure of was described in detail. In total, 21 confirmed cases of COVID-19 were identified in the Ryazan region among 217 TB patients registered at the TB dispensary, which amounted to 9.67%. All TB patients recovered from COVID-19. None of them received anti-cytokine therapy or required mechanical ventilation.
Results. In 4 out of 6 patients with co-infection, COVID-19 occurred with symptoms of moderate intoxication and viral colonization of the upper respiratory tract, without damage to the lung tissue, in 2 – with such damage (in one – CT-1, in the second – CT-2). Patients with background respiratory failure had a moderate course, and those without signs of respiratory failure had a mild course of COVID-19.
Conclusion. Despite the pronounced initial background and somatic burden, 3 patients with chronic pulmonary TB and respiratory failure had a moderate course of coronavirus infection.
Keywords
tuberculosis
COVID-19
respiratory failure
References
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About the Authors
Vitally L. Dobin, MD, Professor, Department of Infectious Diseases and Phthisiology, Academician I.P. Pavlov Ryazan State Medical University, Ryazan, Russia; viladob@gmail.com; orcid.org/0000-0003-1946-5193 ; SPIN 2955-6303Alexey N. Nikolaev, Cand. Med. Sci., Assistant, Department of Infectious Diseases and Phthisiology, Academician I.P. Pavlov Ryazan State Medical University, Ryazan, Russia; nalex12@mail.ru; http://orcid.org/0000-0002-3625-602X
Professor Vladimir A. Martynov, MD, Head, Department of Infectious Diseases and Phthisiology, Academician I.P. Pavlov Ryazan State Medical University, Ryazan, Russia; dr.martinov@mail.ru; https://orcid.org/0000-0002-0117-0613; SPIN 2378- 4380
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